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Vascular myogenic or stretch-dependent tone.

J A Bevan

    Journal of Cardiovascular Pharmacology
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Myogenic tone, a key factor in vascular resistance, relies on vessel wall stretch and external calcium. This process may utilize a unique calcium-entry pathway distinct from other cellular signaling mechanisms.

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    Area of Science:

    • Physiology
    • Vascular Biology
    • Biochemistry

    Background:

    • Myogenic tone significantly contributes to vascular resistance.
    • It plays a crucial role in the autoregulation of blood flow.
    • The precise mechanisms underlying myogenic tone are not fully elucidated.

    Purpose of the Study:

    • To investigate the role of vessel wall stretch in myogenic tone.
    • To determine the dependence of myogenic tone on external calcium.
    • To explore potential calcium-entry mechanisms involved in myogenic tone.

    Main Methods:

    • Studies involving isolated blood vessels.
    • Manipulation of transmural pressure to induce stretch.
    • Assessment of vascular resistance changes.

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  • Pharmacological interventions to investigate calcium dependency.

    • Main Results:

    • Myogenic tone is directly influenced by the stretch of the vessel wall.
    • External calcium is essential for the development of myogenic tone.
    • Evidence suggests a calcium-entry mechanism distinct from agonist-induced pathways.

    Conclusions:

    • Vessel wall stretch is a primary driver of myogenic tone.
    • Calcium influx is critical for myogenic responses.
    • Myogenic tone may involve a novel calcium-entry pathway separate from membrane potential changes or agonist stimulation.