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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...

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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Skin and soft tissue infections.

Rakesh D Mistry1

  • 1Section of Pediatric Emergency Medicine, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, 13123 East 16th Avenue, Box B251, Aurora, CO 80045, USA.

Pediatric Clinics of North America
|October 8, 2013
PubMed
Summary

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) now impacts skin infection treatment. This review covers current epidemiology, evidence-based drainage, and antibiotic strategies for skin and soft tissue infections (SSTIs).

Keywords:
CellulitisCutaneous abscessSkin infectionStaphylococcus aureus

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Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
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Published on: February 9, 2011

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
10:45

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Published on: June 13, 2018

Area of Science:

  • Infectious Diseases
  • Dermatology
  • Microbiology

Background:

  • Skin and soft tissue infections (SSTIs) management has been complicated by the rise of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA).
  • The epidemiology of SSTIs has shifted, necessitating updated clinical practices and treatment protocols.
  • Understanding the evolving landscape of bacterial pathogens is crucial for effective patient care.

Purpose of the Study:

  • To provide an evidence-based overview of the current epidemiology of SSTIs and CA-MRSA.
  • To discuss optimal approaches to incision and drainage for abscesses.
  • To review the role of adjuvant antibiotic therapy and antimicrobial strategies for various SSTIs, including decolonization.

Main Methods:

  • Literature review of current epidemiological data on SSTIs and CA-MRSA.
  • Analysis of evidence supporting incision and drainage techniques.
  • Synthesis of current antimicrobial treatment guidelines and decolonization strategies.

Main Results:

  • CA-MRSA is a significant pathogen in SSTIs, altering traditional treatment paradigms.
  • Incision and drainage remains a cornerstone for purulent SSTIs.
  • Adjuvant antibiotics may be considered in specific scenarios, and decolonization is key for recurrence prevention.

Conclusions:

  • Updated clinical guidelines are essential to manage the impact of CA-MRSA on SSTIs.
  • A comprehensive approach including source control, appropriate antimicrobial therapy, and decolonization is necessary.
  • Further research into optimal treatment and prevention strategies for CA-MRSA SSTIs is warranted.