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Updated: May 7, 2026

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications
Published on: September 2, 2025
[Population-based breast cancer screening: certainties, controversies, and future perspectives]
Luis Apesteguía Ciriza1, Luis Javier Pina Insausti2
1Departamento de Radiología, Complejo Hospitalario de Navarra, Pamplona, España.
Mammography screening for breast cancer shows benefits but faces criticisms regarding mortality reduction and overdiagnosis. Risk stratification and complementary imaging like tomosynthesis may enhance screening effectiveness.
Area of Science:
- Oncology
- Radiology
- Public Health
Background:
- Population-based mammography screening programs are crucial for breast cancer management.
- Debate exists regarding the actual mortality reduction attributed to mammography, with estimates ranging from 12% to 30%.
Purpose of the Study:
- To evaluate the quality and effectiveness of mammography screening programs.
- To discuss criticisms including overdiagnosis and overtreatment.
- To propose improvements for breast cancer screening.
Main Methods:
- Review of existing literature on mammography screening outcomes.
- Analysis of criticisms concerning randomization, tumor progression, and adjuvant treatments.
- Consideration of alternative and complementary diagnostic techniques.
Main Results:
- Mammography screening's impact on breast cancer mortality is debated.
- Concerns persist regarding overdiagnosis and overtreatment.
- Adjuvant treatments also contribute to improved survival rates.
Conclusions:
- While mammography screening is valuable, its effectiveness can be enhanced.
- Risk stratification of patients is a potential improvement.
- Integrating complementary techniques such as tomosynthesis, ultrasonography, and MRI in selected cases may optimize screening outcomes.
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