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Related Experiment Video

Updated: May 7, 2026

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

Published on: March 21, 2018

Prospects for fetal surgery.

N Scott Adzick¹

¹The Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, United States; The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.

Early Human Development

|October 8, 2013

Summary

This summary is machine-generated.

Fetal surgery has advanced significantly, enabling in-utero treatment for conditions like myelomeningocele (MMC). This progress transforms the fetus into a patient, with ongoing research exploring future directions in fetal therapy.

Keywords:

Fetal surgery MOMS trial Management of Myelomeningocele Study Myelomeningocele Prenatal diagnosis Spina bifida

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Area of Science:

Medical science, focusing on fetal medicine and surgical interventions.

Background:

Historically, the womb limited fetal observation and treatment.
Advances in fetal imaging, sampling techniques (amniocentesis, chorionic villus sampling), and animal models have improved understanding of fetal pathophysiology.
Fetal therapy represents a significant advancement, treating the fetus as a patient.

Purpose of the Study:

To review the progress and future prospects of fetal surgery.
To use fetal surgical treatment of myelomeningocele (MMC) as a paradigm for fetal therapy.
To examine the rationale, outcomes, and future research in in utero repair of MMC.

Main Methods:

Review of pathological observations and animal models of MMC.
Analysis of outcomes from human fetal MMC repair.
Inclusion of data from the Management of Myelomeningocele Study (MOMS trial).

Main Results:

Significant progress in the diagnosis and treatment of fetal anatomical abnormalities.
Fetal surgery, exemplified by MMC repair, demonstrates the feasibility of in utero interventions.
The MOMS trial provides crucial data on the outcomes of fetal MMC repair.

Conclusions:

Fetal therapy is a rapidly evolving field, transforming prenatal care.
In utero repair of myelomeningocele shows promise and is a key area of advancement.
Continued research is essential to expand the scope and efficacy of fetal surgical treatments.