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Related Experiment Video

Updated: May 7, 2026

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
07:12

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Published on: January 21, 2020

Type I complex regional pain syndrome.

A-M Gay1, N Béréni, R Legré

  • 1Service de chirurgie de la main et réparatrice des membres, hôpital La-Conception, 147, boulevard Baille, 13385 Marseille cedex 05, France.

Chirurgie De La Main
|October 8, 2013
PubMed
Summary
This summary is machine-generated.

Complex Regional Pain Syndrome (CRPS) is a chronic pain condition often affecting limbs after injury. Early diagnosis and management are crucial for this disabling syndrome.

Keywords:
AlgodystrophieAlgodystrophyComplex regional pain syndromePathophysiologyRevueSDRCISyndrome douloureux régional complexeTreatment

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Area of Science:

  • Pain Medicine
  • Neurology
  • Orthopedics

Background:

  • Complex Regional Pain Syndrome (CRPS) is a poorly understood condition characterized by severe pain disproportionate to the inciting event.
  • Type 1 CRPS (CRPS-I), formerly known as reflex sympathetic dystrophy, affects approximately 25 per 100,000 individuals.
  • CRPS-I commonly occurs after distal radius fractures and carpal tunnel surgery, with upper limb involvement being most frequent.

Purpose of the Study:

  • To define Complex Regional Pain Syndrome (CRPS) and its Type 1 variant (CRPS-I).
  • To highlight key epidemiological factors, including incidence and predisposing conditions.
  • To emphasize the importance of early diagnosis and management for this disabling condition.

Main Methods:

  • Literature review and synthesis of historical and contemporary descriptions of CRPS.
  • Analysis of reported incidence rates and predisposing factors for CRPS-I.
  • Overview of common clinical presentations and treatment modalities.

Main Results:

  • CRPS is defined as an articular and periarticular pain syndrome with vasomotor deregulation, triggered by various stresses.
  • CRPS-I incidence is approximately 25 per 100,000, with female predominance and higher rates in upper limb involvement.
  • CRPS-I is a known complication of distal radius fractures (4-37%) and carpal tunnel surgery (2-4%).

Conclusions:

  • Early diagnosis and prompt management are critical for improving outcomes in CRPS-I due to its potentially long and disabling course.
  • While treatments like NSAIDs, antidepressants, and anticonvulsants offer symptomatic relief, they do not cure CRPS-I.
  • Surgical intervention to remove nociceptive stimuli may yield significant improvements in select CRPS-I cases.