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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
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Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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Related Experiment Video

Updated: May 7, 2026

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain
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Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain

Published on: August 8, 2019

Musculoskeletal imaging using fluoride PET.

Dorothee Rita Fischer1

  • 1Department of Nuclear Medicine, University Hospital Zurich, Rämistrasse, Zurich, Switzerland.

Seminars in Nuclear Medicine
|October 8, 2013
PubMed
Summary
This summary is machine-generated.

Fluoride-18 (18F) PET/CT offers convenient, high-quality imaging for various bone conditions. This technique provides a valuable alternative to traditional methods, especially during shortages of other radiotracers.

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Last Updated: May 7, 2026

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain
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18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography

Published on: January 11, 2020

Area of Science:

  • Nuclear Medicine
  • Radiopharmaceuticals
  • Musculoskeletal Imaging

Background:

  • (18)F-fluoride imaging offers technical advantages like high image quality and short scan times.
  • (18)F-fluoride provides a radiation dose comparable to or slightly higher than 99mTc-based tracers.
  • It serves as a viable alternative to 99mTc-based bone tracers, particularly during molybdenum shortages.

Purpose of the Study:

  • To review the expanding applications of (18)F-fluoride PET/CT in non-oncologic musculoskeletal disorders.
  • To highlight the utility of (18)F-fluoride PET/CT across different skeletal regions and conditions.
  • To assess the potential of (18)F-fluoride PET/CT as a diagnostic and therapeutic management tool.

Main Methods:

  • Review of studies utilizing (18)F-fluoride PET/CT for various non-oncologic musculoskeletal conditions.
  • Inclusion of imaging data from skull, appendicular, and axial skeletons.
  • Evaluation of patient cohorts including those with osteonecrosis, postsurgical changes, foot pain, inflammatory diseases, and post-spine surgery.

Main Results:

  • (18)F-fluoride PET/CT has been investigated for diverse conditions such as bisphosphonate-induced osteonecrosis of the jaw.
  • Studies demonstrated its use in evaluating postsurgical changes, bone grafts, unclear foot pain, ankylosing spondylitis, and Paget disease.
  • Applications include assessing spine fusion surgery outcomes and investigating suspected child abuse and pediatric back pain.

Conclusions:

  • (18)F-fluoride PET/CT shows significant promise for non-oncologic musculoskeletal imaging.
  • Its favorable technical aspects and demonstrated utility suggest increasing future use.
  • (18)F-fluoride PET/CT may serve as an adjunct or alternative to established imaging modalities, aiding therapeutic decision-making.