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Isolation of Murine Embryonic Hemogenic Endothelial Cells
08:56

Isolation of Murine Embryonic Hemogenic Endothelial Cells

Published on: June 17, 2016

A short history of hemogenic endothelium

Gemma Swiers1, Christina Rode, Emanuele Azzoni

  • 1MRC Molecular Haematology Unit, MRC Weatherall Institute of Medicine, John Radcliffe Hospital, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, United Kingdom.

Blood Cells, Molecules & Diseases
|October 8, 2013
PubMed

Definitive hematopoietic cells are generated de novo during ontogeny from a specialized subset of endothelium, the so-called hemogenic endothelium. In this review we give a brief overview of the identification of hemogenic endothelium, explore its links with the HSC lineage, and summarize recent insights into the nature of hemogenic endothelium and the microenvironmental and intrinsic regulators contributing to its transition into blood. Ultimately, a better understanding of the processes controlling the transition of endothelium into blood will advance the generation and expansion of hematopoietic stem cells for therapeutic purposes.

Keywords:
AGMEEHTEndothelial to hematopoietic transitionHSCHSPCHematopoiesisHematopoietic stem cellHemogenic endotheliumMicroenvironmentPASaorta-gonad mesonephrosembryonic dayendothelial-to-hematopoietic transitionhematopoietic stem and/or progenitor cellshematopoietic stem cellpara-aortic splanchnopleura

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