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Related Experiment Video

Updated: May 7, 2026

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Published on: September 11, 2018

Autonomic regulation of kidney function.

Edward J Johns¹

¹Department of Physiology, University College Cork, Cork, Republic of Ireland.

Handbook of Clinical Neurology

|October 8, 2013

Summary

The kidneys regulate cardiovascular homeostasis through fluid balance. Renal sympathetic nerve activity, when dysregulated in diseases like hypertension, can be targeted by renal denervation to normalize blood pressure.

Keywords:

Renal sympathetic nerves autonomic control of the kidney chronic renal disease glomerular filtration rate heart failure hypertension renal blood flow renal denervation sodium excretion

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Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.

Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.

Published on: February 14, 2018

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Last Updated: May 7, 2026

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Published on: September 11, 2018

Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.

Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.

Published on: February 14, 2018

Area of Science:

Nephrology
Cardiovascular Physiology
Autonomic Nervous System

Background:

Kidneys are crucial for cardiovascular homeostasis, maintaining fluid balance and blood pressure.
Renal fluid handling involves neural and humoral influences, with sympathetic nerves responding dynamically to sodium intake.
Sympathetic overactivity in conditions like hypertension can lead to sodium retention and disease exacerbation.

Purpose of the Study:

To elucidate the role of renal sympathetic nerves in cardiovascular homeostasis.
To investigate the impact of renal sympathetic activity in pathophysiological states.
To assess the therapeutic potential of renal denervation in resistant hypertension.

Main Methods:

Integration of information from baroreceptors, somatosensory, visceral, and cortical systems influences renal sympathetic nerve activity.
Analysis of autonomic centers in hypothalamic and medullary brain regions.
Evaluation of renal denervation outcomes in patients with resistant hypertension.

Main Results:

Renal sympathetic nerve activity is modulated by diverse sensory inputs and central autonomic processing.
Inappropriate sympathoexcitation contributes to sodium retention and disease progression in cardiovascular conditions.
Renal denervation in resistant hypertensive patients demonstrated long-term blood pressure normalization.

Conclusions:

Renal sympathetic nerves are key regulators of cardiovascular homeostasis.
Dysregulated renal sympathetic activity exacerbates cardiovascular diseases.
Renal denervation represents a promising therapeutic strategy for resistant hypertension.