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Related Experiment Video

Updated: May 7, 2026

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Published on: August 25, 2022

Neonatal transfusion.

Anne M Kelly¹, Lorna M Williamson

¹University of Cambridge, NHS Blood and Transplant, Department of Haematology (Division of Transfusion Medicine), Long Road, Cambridge, CB2 0PT, United Kingdom.

Early Human Development

|October 8, 2013

Summary

This summary is machine-generated.

Neonatal transfusion practices are improving with better evidence for red cell transfusion triggers. While transfusions are safe, rare complications like transfusion-associated circulatory overload (TACO) may be underdiagnosed in critically ill preterm infants.

Keywords:

Albumin Coagulation Cryoprecipitate Fresh frozen plasma Haemovigilance Intravenous immunoglobulin Neonate Platelets Preterm Red cells Transfusion

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Area of Science:

Neonatal Medicine
Hematology
Pediatric Critical Care

Background:

Neonates, especially preterm infants, receive significant blood product volumes relative to body weight.
Historically, robust evidence for transfusion practices in neonates was limited but is now expanding.
Transfusion safety has improved, yet certain complications may be underrecognized in vulnerable infants.

Purpose of the Study:

To review current practices and rationale for blood component therapy in neonates.
To provide background on component specifications and transfusion hazards.
To discuss indications for red blood cells, platelets, and plasma, with case examples.

Main Methods:

Literature review of current evidence and guidelines for neonatal transfusion.
Summary of blood component specifications and known transfusion risks.
Discussion of clinical indications for specific blood products.

Main Results:

Evidence for red cell transfusion triggers is becoming better defined.
Ongoing trials are expected to provide similar evidence for platelet transfusions.
Transfusion-associated acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO) are potential risks, possibly underdiagnosed.

Conclusions:

Current evidence supports refined transfusion triggers for neonates.
Blood component therapy is generally safe, but vigilance for complications is necessary.
Understanding indications and risks is crucial for optimizing neonatal transfusion practice.