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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...

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Related Experiment Video

Updated: May 7, 2026

Effects of Desmodium caudatum on Gastrointestinal Hormones and Intestinal Flora in Rats with Gastritis
03:48

Effects of Desmodium caudatum on Gastrointestinal Hormones and Intestinal Flora in Rats with Gastritis

Published on: March 1, 2024

[The relationship between selenium and gastrointestinal inflammatory diseases].

Dániel Tamás Nagy1, Béla Fülesdi, Judit Hallay

  • 1Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Aneszteziológiai és Intenzív Terápiás Tanszék Debrecen Nagyerdei krt. 98. 4032.

Orvosi Hetilap
|October 8, 2013
PubMed
Summary

Selenium (Se) supplementation may help manage inflammatory bowel diseases (IBD) by reducing oxidative stress and supporting gut immunity. While human studies show benefits in reducing disease severity, animal models suggest a preventive role for Se in IBD and colon cancer.

Keywords:
Crohn-betegségCrohn’s diseaseIBDglutathione peroxidaseglutation-peroxidázgyulladásos bélbetegségseleniumszelén

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DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
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DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

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Last Updated: May 7, 2026

Effects of Desmodium caudatum on Gastrointestinal Hormones and Intestinal Flora in Rats with Gastritis
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DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
09:04

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

Area of Science:

  • Biochemistry
  • Immunology
  • Gastroenterology

Context:

  • Reactive oxygen and nitrogen species (RONS) contribute to gastrointestinal diseases.
  • Inflammatory bowel diseases (IBD) are linked to malnutrition and impaired gut immunity.
  • Selenium (Se) is a crucial trace element in antioxidant defense systems.

Purpose:

  • To explore the role of selenium (Se) in the context of inflammatory bowel diseases (IBD).
  • To investigate the impact of Se on oxidative stress, gut immunity, and disease severity in IBD patients and animal models.

Summary:

  • IBD is associated with lower serum Se levels, reduced antioxidant capacity, and increased inflammation.
  • Se, as part of glutathione peroxidase, supports gut-associated lymphoid tissue (GALT) immunity.
  • Nutritional therapy, including Se supplementation, is vital for managing IBD.

Impact:

  • Adequate Se repletion may decrease organ failure and infection severity in IBD patients, though not mortality.
  • Animal studies indicate a preventive effect of Se against IBD and inflammation-induced colon cancer.
  • Further research into Se's role in IBD pathogenesis and therapy is warranted.