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Role of Myc in hepatocellular proliferation and hepatocarcinogenesis

Aijuan Qu1, Changtao Jiang1, Yan Cai1

  • 1Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States.

Journal of Hepatology
|October 8, 2013
PubMed
Abstract

Keywords:
Acox1BrdUCDKCell cycle controlCell proliferationChek1Cre-ER(T2)Cyp4a10 and Cyp4a14DENMcmMycMyc(fl/fl)Myc(fl/fl)Mx-CreMyc(fl/fl,ERT2-Cre)PPARαRAD51 homolog (S. cerevisiae)Rad51SATumorigenesisacyl-CoA oxidasebHLHbasic helix-loop-helix leucine zipperbromodeoxyuridinecheckpoint kinase 1 homologuecre recombinase, tamoxifen-inducible estrogen receptor ligand-binding domain fusion proteincyclin-dependent kinasecytochromes P450 4a10 and 4a14diethynitrosaminefloxed Myc alleleinducible liver-specific Myc knockout mouseminichromosome maintenanceperoxisome proliferator-activated receptor αserum albumin promoterα/β interferon-inducible Mx-promoter driving Cre recombinase

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