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Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
08:30

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation

Published on: August 14, 2017

Treating symptomatic coronary artery disease in patients with Von Willebrand disease

Syed A Hassan1, Syed Amer, Waqas Qureshi

  • 1Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.

Hematology/Oncology and Stem Cell Therapy
|October 8, 2013
PubMed

Insights

This study reviewed 198 patients with Von Willebrand disease, finding 6 with symptomatic coronary artery disease (CAD). Management included stenting, bypass grafting, or medical therapy, with antiplatelets generally well-tolerated.

Area of Science:

  • Cardiology
  • Hematology

Background:

  • Limited data exists on coronary artery disease (CAD) prevalence and management in patients with Von Willebrand disease (VWD).
  • Von Willebrand disease is a common inherited bleeding disorder, potentially impacting cardiovascular health management.

Observation:

  • A 15-year review of 198 Von Willebrand disease patients identified 6 with symptomatic coronary artery disease.
  • Three patients presented with acute coronary syndrome, and three with stable angina.

Findings:

  • Cardiac catheterization revealed the left main coronary artery as the culprit lesion in all affected patients.
  • Management strategies included percutaneous coronary intervention (stenting), coronary artery bypass grafting, and medical management.
  • Antiplatelet therapy (aspirin, clopidogrel) was used with minimal reported side effects.

Implications:

  • This study highlights the importance of considering coronary artery disease in Von Willebrand disease patients.
  • Further research is needed to establish optimal, evidence-based management guidelines for this specific patient population.
  • Understanding CAD in VWD patients can improve diagnostic and therapeutic approaches, potentially reducing adverse cardiovascular events.

Keywords:
Acute coronary syndromeCoronary artery diseaseVon Willebrand disease

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