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Related Experiment Videos

Hemoconcentration during open heart operations.

V P Osipov, G O Lurie, Khodas MYa

    The Thoracic and Cardiovascular Surgeon
    |April 1, 1985
    PubMed
    Summary
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    Hemoconcentration using blood ultrafiltration effectively controls hemodilution during extracorporeal circulation, preserving plasma proteins and reducing blood loss. This safe method is ideal for open-heart surgeries, especially in patients with renal issues.

    Area of Science:

    • Cardiovascular Surgery
    • Nephrology
    • Biomedical Engineering

    Background:

    • Extracorporeal circulation during surgery can lead to hemodilution.
    • Managing hemodilution is crucial for patient outcomes.
    • Existing methods like plasmapheresis may remove beneficial plasma proteins.

    Purpose of the Study:

    • To evaluate hemoconcentration via ultrafiltration for hemodilution control in patients undergoing extracorporeal circulation.
    • To assess the safety and efficacy of this method compared to alternatives.

    Main Methods:

    • Ultrafiltration using disposable plate or hollow fiber dialyzers and a specialized hemoconcentrator.
    • Application in 84 patients during surgical procedures with heart-lung bypass.
    • Monitoring ultrafiltrate volume and comparing it to cardioplegic solution administration.

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    Main Results:

    • Mean ultrafiltrate volume was 2588 +/- 221 cc per patient.
    • The method is simple, safe, and effective in controlling hemodilution.
    • Preserves plasma proteins, unlike centrifuging methods.
    • Reduces blood loss and the need for bank blood.
    • No significant humoral homeostasis disturbances observed.

    Conclusions:

    • Hemoconcentration by ultrafiltration is a recommended method for hemodilution control during extracorporeal circulation.
    • Particularly indicated for patients with renal insufficiency and profound hemodilution.
    • Can be routinely used in open-heart surgery settings.
    • Requires increased electrolyte solution administration during bypass.