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Social Exchange Theory01:26

Social Exchange Theory

As formulated by John Thibaut and Harold Kelley, Social Exchange Theory explains human relationships as economic-like exchanges that maximize rewards and minimize costs. This theory suggests that individuals engage in relationships to gain benefits and reduce burdens, similar to economic transactions. It has been widely applied to various types of relationships, including romantic, professional, and social interactions.Rewards and Costs in RelationshipsRelationship rewards include emotional...
Social Exchange Theory02:06

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We have discussed why we form relationships, what attracts us to others, and different types of love. But what determines whether we are satisfied with and stay in a relationship? One theory that provides an explanation is social exchange theory. According to social exchange theory, we act as naïve economists in keeping a tally of the ratio of costs and benefits of forming and maintaining a relationship with others (Rusbult & Van Lange, 2003).
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A Versatile Automated Platform for Micro-scale Cell Stimulation Experiments
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MDM2's social network.

R Fåhraeus1, V Olivares-Illana2

  • 1Cibles Therapeutiques, Equipe Labellisée Ligue Contre le Cancer, INSERM Unité 940, Institut de Génétique Moléculaire, Université Paris 7, Hôpital St Louis, 27 rue Juliette Dodu, Paris, France.

Oncogene
|October 8, 2013
PubMed
Summary
This summary is machine-generated.

The MDM2 protein interacts with numerous partners, regulating diverse cellular processes like protein synthesis and transcription. This review details MDM2

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Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Protein Interactions

Background:

  • MDM2 (mouse double minute 2 homolog) is a crucial hub protein known for its extensive interactions.
  • Its primary characterized function is as an E3 ubiquitin ligase, impacting protein stability and degradation.
  • MDM2's diverse roles extend beyond ubiquitination, involving regulation of transcription, translation, and cellular stress responses.

Purpose of the Study:

  • To comprehensively review and catalog known MDM2 interactions.
  • To elucidate the mechanisms by which MDM2 interacts with a wide array of substrates.
  • To highlight MDM2's central role as an intermediary in various signaling pathways.

Main Methods:

  • Literature review of published studies on MDM2 interactions.
  • Analysis of reported MDM2 binding partners and their functional relevance.
  • Discussion of post-translational modifications and isoforms affecting MDM2 function.

Main Results:

  • MDM2 interacts with diverse partners, including p53, nucleotides, mRNA, DNA, kinases, ribosomal proteins, and proteases.
  • Interactions are linked to MDM2's E3 ligase activity, regulatory functions, and roles in transcription and translation.
  • MDM2 exhibits plasticity, enabling its pleiotropic functions through various post-translational modifications and isoforms.

Conclusions:

  • MDM2's extensive and diverse interactome underscores its multifaceted nature and critical role in cellular regulation.
  • Understanding MDM2's interactions is key to deciphering its involvement in fundamental cellular processes and disease.
  • This review provides a consolidated resource for the vast landscape of MDM2 interactions and their functional implications.