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Updated: May 7, 2026

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
Published on: June 27, 2022
Hydrogen sulfide and translational medicine
Wei Guo1, Ze-Yu Cheng, Yi-Zhun Zhu
1Department of Pharmacology, School of Pharmacy, Shanghai 201203, China.
Hydrogen sulfide (H2S) is a vital signaling molecule, but its effects vary. Developing H2S donors with sustained release is crucial for scientific and clinical applications.
Area of Science:
- Biochemistry
- Physiology
- Pharmacology
Background:
- Hydrogen sulfide (H2S) is a key gasotransmitter alongside carbon monoxide and nitric oxide.
- H2S participates in regulating homeostasis, vascular tone, inflammation, and apoptosis.
- The physiological effects of H2S are concentration, time, and cell-type dependent, leading to varied outcomes.
Purpose of the Study:
- To review the physiological and pathological roles of H2S.
- To discuss the limitations of current H2S donors.
- To highlight the potential of sustained-release H2S donors in translational medicine.
Main Methods:
- Literature review of H2S research.
- Analysis of H2S donor mechanisms.
- Discussion of H2S delivery strategies.
Main Results:
- H2S exhibits diverse biological activities.
- Existing H2S donors have limitations due to rapid release and short half-life.
- Controlled H2S donation offers therapeutic potential.
Conclusions:
- Sustained and controlled H2S release is essential for therapeutic development.
- Further research into H2S-releasing drugs and donor molecules is warranted.
- Manipulating H2S delivery presents promising avenues for future investigations.
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