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Related Experiment Videos

Growth hormone and Klotho.

Christoph Schmid1, Marian C Neidert, Oliver Tschopp

  • 1Division of Endocrinology and Diabetology, University Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland Department of Neurosurgery, University Hospital Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland Division of Endocrinology and Diabetology, Kantonsspital St Gallen, 9007 St Gallen, Switzerland Department of Neurosurgery, Clinic Hirslanden, Witellikerstrasse 40, 8032 Zurich, Switzerland.

The Journal of Endocrinology
|October 8, 2013
PubMed
Summary
This summary is machine-generated.

Soluble Klotho (sKlotho) is elevated in active acromegaly and normalizes after pituitary adenoma removal. Measuring sKlotho in serum and urine may aid acromegaly diagnosis and monitoring.

Keywords:
FGF23IGF1Klothoacromegalygrowth hormone

Related Experiment Videos

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Gerontology

Background:

  • Acromegaly involves elevated growth hormone (GH) and insulin-like growth factor 1 (IGF1).
  • Recent findings indicate increased soluble Klotho (sKlotho) in active acromegaly patients.
  • sKlotho levels decrease post-pituitary adenoma removal.

Purpose of the Study:

  • To investigate the role of soluble Klotho (sKlotho) in acromegaly.
  • To explore the relationship between GH, sKlotho, and kidney function.
  • To assess the potential of sKlotho as a diagnostic marker for acromegaly.

Main Methods:

  • Measurement of sKlotho levels in serum and urine using ELISA.
  • Analysis of sKlotho concentrations in relation to acromegaly activity.
  • Comparison of sKlotho levels before and after pituitary adenoma treatment.

Main Results:

  • Elevated sKlotho levels were observed in patients with active acromegaly.
  • sKlotho levels normalized after surgical removal of GH-producing pituitary adenomas.
  • sKlotho concentrations are particularly high in urine and cerebrospinal fluid (CSF).

Conclusions:

  • sKlotho may serve as a supplementary diagnostic and monitoring tool for acromegaly.
  • GH influences renal phosphate reabsorption and calcitriol production, potentially interacting with Klotho pathways.
  • Further research is needed to elucidate the precise mechanisms of GH action on Klotho activity.