Structure and function of voltage-gated sodium channels at atomic resolution

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William A Catterall1

  • 1W. A. Catterall: Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195-7280, USA. wcatt@u.washington.edu.

Experimental Physiology
|October 8, 2013
PubMed

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Voltage-gated Ion Channels

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A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
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Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...