Related Experiment Video
Updated: May 7, 2026

In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
Published on: September 23, 2021
Harnessing immune responses in the tumor microenvironment: all signals needed
Dung T Le1, Elizabeth M Jaffee
1Authors' Affiliation: The Sidney Kimmel Cancer Center at Johns Hopkins University School of Medicine, Baltimore, Maryland.
Abstract:
An agonist CD40 monoclonal antibody (CP-870,893), in combination with gemcitabine, is well tolerated in patients with advanced pancreatic adenocarcinoma. The combination results in induction of cytokines, B cell activation, and clinical responses. These findings support testing of immunotherapies in combination with other established and targeted therapies.
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