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Updated: May 7, 2026
09:43
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Damage in lupus patients--what have we learned so far?
L Eder1, M B Urowitz, D D Gladman
1University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Canada.
Lupus
|October 8, 2013
Summary
Systemic Lupus Erythematosus (SLE) patients require careful monitoring to prevent organ damage. Promptly controlling disease activity and adjusting medications like corticosteroids are crucial for minimizing cumulative damage.
Area of Science:
- Rheumatology and Immunology
- Clinical Medicine
Background:
- Improved survival in Systemic Lupus Erythematosus (SLE) necessitates a focus on preventing cumulative organ damage.
- The Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index (SDI) was developed to standardize damage assessment.
Purpose of the Study:
- To highlight the importance of assessing cumulative organ damage in SLE patients.
- To emphasize the relationship between disease activity, treatment, and organ damage.
Main Methods:
- Utilized the SLICC/ACR damage index (SDI) for standardized damage measurement.
- Analyzed factors influencing damage accrual in SLE patients.
Main Results:
- Damage accrues over time in SLE, but varies among patients.
- Higher disease activity correlates with increased damage rates.
- Medications, particularly corticosteroids, can contribute to organ damage.
Conclusions:
- Effective management of SLE requires balancing disease control with minimizing treatment-induced damage.
- Regular assessment using tools like the SDI is vital for long-term patient care.
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