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Rosette formation in malignant lymphoma.

G Frizzera, K Gajl-Peczalska, R K Sibley

    The American Journal of Pathology
    |June 1, 1985
    PubMed
    Summary
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    Rosette structures, typically seen in neuroepithelial tumors, were observed in follicular lymphoma lymph nodes. This finding suggests rosettes do not exclude lymphoma diagnosis.

    Area of Science:

    • Oncology
    • Pathology
    • Cell Biology

    Background:

    • Follicular lymphoma is a common type of non-Hodgkin lymphoma.
    • Neuroepithelial neoplasms are tumors originating from nerve tissue.
    • Rosette structures are characteristic microscopic findings in certain tumors.

    Observation:

    • Lymph node biopsies from a follicular lymphoma patient unexpectedly revealed rosette formations.
    • These rosettes consisted of neoplastic lymphocytes surrounding eosinophilic fibrillary material.
    • Histologic, immunoperoxidase, immunofluorescence, and electron microscopy were employed for detailed analysis.

    Findings:

    • Ultrastructural examination showed the fibrillary material comprised cytoplasmic processes from lymphocytes.
    • Immunohistochemistry confirmed neoplastic lymphocytes expressing monoclonal IgM lambda and other lymphoma markers.

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  • The material weakly stained for vimentin and actin, with lymphocytes showing surface changes.

    • Implications:

    • The presence of rosettes in lymph node biopsies should not be used to rule out lymphoma.
    • Rosettes may represent activated neoplastic lymphocytes responding to microenvironmental stimuli.
    • This hitherto unreported finding expands the differential diagnosis for rosette-forming lesions.