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Related Concept Videos

2° Amines to N-Nitrosamines: Reaction with NaNO201:20

2° Amines to N-Nitrosamines: Reaction with NaNO2

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Secondary amines react with nitrous acid to form N-nitrosamines, as depicted in Figure 1. Nitrous acid, a weak and unstable acid, is formed in situ from an aqueous solution of sodium nitrite and strong acids, such as hydrochloric acid or sulfuric acid, in cold conditions. In the presence of an acid, the nitrous acid gets protonated. The subsequent loss of water results in the formation of the electrophile known as nitrosonium ion.
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Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles01:11

Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles

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Naming Amides
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
4.3K
Nomenclature of Aryl and Heterocyclic Amines01:10

Nomenclature of Aryl and Heterocyclic Amines

2.3K
The simplest aromatic amine is phenylamine, which contains an –NH2 functionality directly attached to an aromatic ring. The name aniline is designated for this skeleton. As shown in Figure 1, the common names of the functionalized anilines involve prefixes ortho-, meta-, and para- to indicate the substitution position. Different functionalized aniline derivatives also have notable trivial names.
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Physical Properties of Amines01:26

Physical Properties of Amines

3.2K
Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.
3.2K
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism01:37

1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism

3.3K
Nitrous acid is a relatively weak and unstable acid prepared in situ by the reaction of sodium nitrite and cold, dilute hydrochloric acid. In an acidic solution, the nitrous acid undergoes protonation when it loses water to form a nitrosonium ion—an electrophile. Nitrous acid reacts with primary amines to give diazonium salts. The reaction is called diazotization of primary amines.
3.3K
Carboxylic Acids to Methylesters: Alkylation using Diazomethane01:33

Carboxylic Acids to Methylesters: Alkylation using Diazomethane

2.3K
Carboxylic acids react with diazomethane in an ether solvent via alkylation at the carboxylate oxygen atom to give methyl esters of the corresponding acid with excellent yields.
2.3K

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N-(2-Nitro-phen-yl)furan-2-carboxamide.

Rodolfo Moreno-Fuquen1, Alexis Azcárate, Alan R Kennedy

  • 1Departamento de Química - Facultad de Ciencias, Universidad del Valle, Apartado 25360, Santiago de Cali, Colombia.

Acta Crystallographica. Section E, Structure Reports Online
|October 8, 2013
PubMed
Summary

This study details the molecular structure of a furan-carboxamide derivative (C11H8N2O4). Researchers analyzed the crystal packing, revealing helical chains formed by weak intermolecular interactions.

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Area of Science:

  • Organic Chemistry
  • Crystallography
  • Molecular Structure Analysis

Background:

  • Furan-carboxamide derivatives are important scaffolds in medicinal chemistry.
  • Understanding the three-dimensional structure of such compounds is crucial for predicting their properties and interactions.

Purpose of the Study:

  • To elucidate the detailed molecular geometry of a specific furan-carboxamide derivative (C11H8N2O4).
  • To investigate the intermolecular interactions and crystal packing of this compound.

Main Methods:

  • Single-crystal X-ray diffraction was employed to determine the molecular structure.
  • Analysis of bond lengths, bond angles, and dihedral angles provided geometric insights.
  • Crystal structure analysis identified intermolecular interactions and packing motifs.

Main Results:

  • The benzene and furan rings exhibit distinct rotations (2.68° and 7.03°, respectively) from the central plane.
  • A dihedral angle of 10.15° was observed between the nitro group and the adjacent benzene ring.
  • Weak C-H⋯O interactions facilitate the formation of helical chains along the [010] direction in the crystal lattice.

Conclusions:

  • The study provides precise structural data for the furan-carboxamide derivative C11H8N2O4.
  • The observed molecular conformation and crystal packing are influenced by specific dihedral angles and intermolecular forces.
  • The helical chain arrangement offers insights into the solid-state behavior of this class of compounds.