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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Hepatotoxicity of antibiotics: a review and update for the clinician

Jonathan G Stine1, James H Lewis

  • 1Division of Gastroenterology and Hepatology, Department of Medicine, Georgetown University Medical Center, 3800 Reservoir Road, NW Room M2408, Washington, DC 20007, USA.

Clinics in Liver Disease
|October 9, 2013
PubMed

Insights

Antibiotics can cause drug-induced liver injury (DILI), complicating diagnosis due to short therapy and other factors. This review updates information on antimicrobial agents causing DILI, including new and older drugs.

Area of Science:

  • Hepatology
  • Pharmacology
  • Infectious Diseases

Background:

  • Drug-induced liver injury (DILI) is a significant concern with antibiotic use.
  • Diagnosing acute antibiotic-associated DILI is challenging due to brief treatment courses and confounding factors.
  • The underlying infection treated by antibiotics can also contribute to liver dysfunction.

Purpose of the Study:

  • To review and summarize information on various antibiotic classes associated with DILI.
  • To highlight newly identified antimicrobial agents causing DILI.
  • To provide updated information on DILI caused by established antimicrobial agents.

Main Methods:

  • Literature review of antibiotic-induced hepatotoxicity.
  • Summarization of clinical and pathological data on DILI.
  • Focus on both new and older antimicrobial agents.

Main Results:

  • Antibiotics are a primary cause of drug-induced liver injury.
  • Hepatotoxicity from antimicrobials presents a broad clinicopathologic spectrum.
  • Newer and older antimicrobial agents are implicated in DILI.

Conclusions:

  • Antibiotic-associated DILI requires careful consideration in clinical practice.
  • Understanding the spectrum of hepatotoxicity is crucial for accurate diagnosis.
  • This review offers updated insights into antimicrobial agents and DILI.
Keywords:
AntibioticsDrug safetyDrug-induced liver injuryMonitoring

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