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Updated: May 7, 2026

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Published on: May 16, 2019
Drug-induced liver injury from antiepileptic drugs
Jennifer S Au1, Paul J Pockros
1Division of Gastroenterology/Hepatology, Scripps Clinic, and Scripps Translational Science Institute, 10666 North Torrey Pines Road, La Jolla, CA 92037, USA.
Abstract:
Drug-induced liver injury is a potential complication of innumerable medications. Most cases do not occur in a predictable, dose-dependent manner, leading to delayed recognition of a drug's hepatotoxic potential until after its release into the market. The estimated occurrence is 1 in 10,000 to 100,000 patients. However, the rates are likely higher because many cases go unrecognized owing to lack of reporting or missed diagnosis. This article reviews the most commonly associated antiepileptic drugs.
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