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Related Concept Videos

Acne Infection01:27

Acne Infection

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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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FDA Approved Drugs: Changes to Approved Drugs01:26

FDA Approved Drugs: Changes to Approved Drugs

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Post-approval, manufacturers may modify an approved new or generic drug product. Such modifications can encompass alterations in the Active Pharmaceutical Ingredient (API), manufacturing process, formulation, batch size, manufacturing site, and container closure system (FDA Guidance for Industry, April 2004). Often, a drug product may undergo multiple changes.These modifications require careful evaluation to determine their potential impact on the drug product's identity, strength, quality,...
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Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

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Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Drug Dosage Regimen: Overview01:15

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A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Advances in Gentle Polymeric Cleansing Technologies.

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Significantly Enhanced Improvement in Dryness, Roughness, Fine Lines and Radiance Following Daily Use of a Novel Multi-Weight Hyaluronic Acid Plus Antioxidant Complex-Based Lotion Compared to a Single-Weight HA Plus Ceramide-Based Lotion.

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Related Experiment Video

Updated: May 7, 2026

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid
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Isotretinoin updates.

Shelbi C Jim On1, Joshua Zeichner

  • 1Department of Dermatology, The Mount Sinai School of Medicine, New York, New York, USA.

Dermatologic Therapy
|October 9, 2013
PubMed
Summary

Isotretinoin effectively treats severe acne vulgaris, a common skin condition impacting quality of life. Careful monitoring is crucial due to potential rare but serious side effects like depression and inflammatory bowel disease.

Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Acne vulgaris is a chronic inflammatory pilosebaceous disease affecting adolescents and young adults.
  • It significantly impacts psychological well-being and quality of life.
  • Effective treatment improves patient self-esteem and life quality.

Purpose of the Study:

  • To review the efficacy and side effect profile of isotretinoin in acne vulgaris treatment.
  • To highlight the importance of dose-dependent side effects and monitoring.

Main Methods:

  • Literature review of isotretinoin's use in acne vulgaris over the past 30 years.
  • Analysis of treatment outcomes and adverse event data.

Main Results:

  • Isotretinoin has revolutionized severe cystic acne treatment.
Keywords:
acneisotretinoinupdates

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  • Most side effects are predictable and dose-dependent, managed by variable dosing.
  • Rare but significant side effects, including depression and inflammatory bowel disease, necessitate careful patient monitoring.

    • Conclusions:

    • Isotretinoin is a highly effective acne treatment, particularly for severe cases.
    • Variable dosing strategies help manage predictable side effects.
    • Vigilant monitoring is essential to mitigate risks of rare but severe adverse events and optimize clinical outcomes.