Pd(II)-catalyzed Ph2(O)P-directed C-H olefination toward phosphine-alkene ligands
Hong-Li Wang1, Rong-Bin Hu, Heng Zhang
1State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China , and State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics , Lanzhou 730000, P. R. China.
Abstract:
The Pd(II)-catalyzed Ph2(O)P-directed C-H olefination to synthesize alkene-phosphine compounds is reported. In contrast to previous examples of various directing groups that guide selective C-H activation, the Ph2(O)P group not only acts as the directing group but also serves to construct the alkene-phosphine ligands. The monoprotected amino acid (MPAA) ligand Ac-Leu-OH is found to promote this reaction in a significant manner.
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