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Effect of cadmium on rat Leydig cell testosterone production and DNA integrity in vitro

Qing Liu1, Jian Hong Gu, Yan Yuan

  • 1Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonoses; Department of Veterinary clinical Medicine, Veterinary Medicine College, Yangzhou University, Yangzhou, 225009, Jiangsu, China.

Biomedical and Environmental Sciences : BES
|October 9, 2013
PubMed
Abstract

No abstract available in PubMed .

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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