Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pore Transport and Ion-Pair Transport01:17

Pore Transport and Ion-Pair Transport

1.6K
Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited  but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
1.6K
Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

4.8K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
4.8K
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

4.6K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coupling of Electrostatic Interactions and Electroosmotic Flow in the Translocation of a Single-Stranded RNA through Charged Nanopores.

The journal of physical chemistry. B·2026
Same author

Random Walking Dynamics of a DNA Nanorobot on a Two-Dimensional Nanopore Track.

The journal of physical chemistry. B·2025
Same author

Knotting and adsorption of end-grafted active polymers.

Soft matter·2025
Same author

Autonomous walking dynamics of a nanorobot on a nanopore track driven by salt concentration gradients.

The Journal of chemical physics·2025
Same author

Investigation of Polymer Chain Diffusion Behavior in Thin Slits Formed by Patch-Patterned Surfaces: Influence of Patch Properties.

Langmuir : the ACS journal of surfaces and colloids·2024
Same author

Langevin Dynamics Study on the Driven Translocation of Polymer Chains with a Hairpin Structure.

Molecules (Basel, Switzerland)·2024

Related Experiment Video

Updated: May 7, 2026

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

16.3K

Study on the polymer translocation induced blockade ionic current inside a nanopore by Langevin dynamics simulation.

Li-Zhen Sun1, Meng-Bo Luo

  • 1Department of Physics, Zhejiang University, Hangzhou 310027, People's Republic of China.

Journal of Physics. Condensed Matter : an Institute of Physics Journal
|October 9, 2013
PubMed
Summary

Ionic current blockade during polymer translocation through nanopores depends on polymer properties and pore interactions. Factors like volume fraction and polymer charge significantly influence ion flow, with conformation playing a complex role.

More Related Videos

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

11.4K
Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example
08:42

Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example

Published on: October 26, 2016

11.7K

Related Experiment Videos

Last Updated: May 7, 2026

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

16.3K
Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

11.4K
Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example
08:42

Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example

Published on: October 26, 2016

11.7K

Area of Science:

  • Nanotechnology
  • Polymer Physics
  • Physical Chemistry

Background:

  • Understanding ion transport through nanopores is crucial for biosensing and filtration technologies.
  • Polymer translocation dynamics influence pore conductance, affecting device performance.

Purpose of the Study:

  • To investigate the factors governing ionic current blockade during polymer translocation in nanopores.
  • To elucidate the relationship between polymer characteristics and ion flow modulation.

Main Methods:

  • Utilized a three-dimensional Langevin dynamics method for simulation.
  • Analyzed the blockade ionic current (IB) in relation to polymer length (N), configuration, charge (Ztot), and pore interactions.

Main Results:

  • Ionic current blockade (IB) increases with volume vacancy fraction (fV) and decreases with increasing absolute total charge (|Ztot|).
  • Polymer conformation's effect on IB is complex, depending on polymer radius of gyration (RG) and pore size (s).
  • Strong polymer-pore attraction leads to increased IB by concentrating monomers near the pore surface.

Conclusions:

  • Polymer translocation significantly alters nanopore ionic current through interplay of physical and chemical factors.
  • Predictive models of ion transport must account for polymer conformation, charge, and pore interactions for accurate simulations.