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Updated: May 7, 2026
09:06
In vivo Imaging of Biological Tissues with Combined Two-Photon Fluorescence and Stimulated Raman Scattering Microscopy
Published on: December 20, 2021
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Lucky to meet RS3PE.
Cláudia Ferrao1, Raquel M Faria, Pedro Farrajota
1Department of Medicine, Hospital Santo António, Porto, Portugal.
BMJ Case Reports
|October 9, 2013
Summary
A rare autoimmune arthritis, remitting seronegative symmetrical synovitis with pitting edema, was found to be a paraneoplastic syndrome. This diagnosis led to the early detection of an asymptomatic adenosquamous lung carcinoma, enabling curative treatment.
Area of Science:
- Rheumatology
- Oncology
- Pulmonology
Background:
- Remitting seronegative symmetrical synovitis with pitting edema (RS3P) is a rare arthritis presentation.
- Paraneoplastic syndromes can manifest with diverse rheumatological symptoms.
- Undiagnosed lung cancer is a significant public health concern.
Observation:
- A patient presented with florid RS3P and pitting edema.
- Standard autoimmune markers for synovitis were negative (seronegative).
- The patient was asymptomatic for pulmonary malignancy.
Findings:
- The RS3P was identified as a paraneoplastic manifestation.
- The underlying cause was an asymptomatic adenosquamous lung cell carcinoma.
- Arthritis prompted lung cancer screening, leading to early diagnosis.
Implications:
- Highlights the importance of investigating unusual arthritis presentations for underlying malignancy.
- Demonstrates how paraneoplastic arthritis can be the sole presenting sign of lung cancer.
- Early diagnosis of lung cancer via arthritis screening allows for potentially curative intervention.
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