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Reversible and competitive inhibitory kinetics of amoxicillin on mushroom tyrosinase

Xiao-Xin Chen1, Jian Zhang, Wei-Ming Chai

  • 1Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen 361005, China.

International Journal of Biological Macromolecules
|October 9, 2013
PubMed

Keywords:
AmoxicillinDMSOFluorescence quenchingIC50K(I)K(IS)Molecular dockingMolecular mechanismMushroom tyrosinasedimethyl sulfoxideequilibrium constant of the inhibitor combining with the enzyme–substrate complexequilibrium constant of the inhibitor combining with the free enzymel-3,4-dihydroxyphenylalaninel-DOPAl-Tyrl-tyrosinethe inhibitor concentrations leading to 50% activity lost

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