Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Vaccinations

Vaccinations

Vaccine Production

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...

Vaccines

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the...

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Computational modelling approaches to vaccinology.

Pharmacological research·2014

Same author

Proteins accessible to immune surveillance show significant T-cell epitope depletion: Implications for vaccine design.

Molecular immunology·2009

Same author

The HLA-A2-supermotif: a QSAR definition.

Organic & biomolecular chemistry·2003

Same author

Microarrays in hematology.

Current opinion in hematology·2001

Search research articles

Related Experiment Video

Updated: May 7, 2026

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development

Published on: June 19, 2018

Computer-Aided Vaccine Design.

Darren Flower¹

¹Life and Health Sciences; Aston University; Birmingham, West Midlands UK.

Human Vaccines & Immunotherapeutics

|October 9, 2013

Summary

Computer-aided methods are revolutionizing vaccine discovery, moving beyond traditional empirical approaches. This shift enables a more rational and efficient design of vaccines and their components.

Area of Science:

Biomedical Science
Vaccinology
Computational Biology

Background:

Vaccine discovery has historically relied on empirical methods.
A transition towards rational, data-driven approaches is emerging.
Computational methods are increasingly vital in modern biomedical research.

Approach:

The book "Computer-Aided Vaccine Design" by Tong and Ranganathan is reviewed.
It highlights the application of computer-based methods in vaccine development.
The text addresses the computational discovery of vaccines and their components.

Key Points:

Emphasizes the shift from empirical to rational vaccine design.
Showcases the role of computational tools in accelerating discovery.
Covers the design of both vaccines and their individual components.

Keywords:

adjuvant disocovery immunoinformatics rational design vaccine vaccine design vaccine discovery

More Related Videos

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Published on: May 6, 2015

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Published on: April 29, 2015

Related Experiment Videos

Last Updated: May 7, 2026

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development

Published on: June 19, 2018

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Published on: May 6, 2015

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Published on: April 29, 2015

Conclusions:

Computer-aided vaccine design represents a significant advancement in the field.
This approach enhances the efficiency and rationality of vaccine development.
The book serves as a valuable resource for researchers in computational vaccinology.