[Pemphigoid gestationis: light microscopic and direct immunofluorescense findings]

Area of Science:

• Dermatology
• Immunodermatology
• Obstetrics

Background:

• Pemphigoid gestationis (PG) is a rare, autoimmune blistering disease specific to pregnancy.
• It typically manifests in the second or third trimester with intense itching and characteristic skin lesions.

Observation:

• The case involves a 33-year-old pregnant woman presenting with generalized pruritus.
• Skin examination revealed pruritic, urticarial plaques progressing to tense vesicles and bullae.

Findings:

• Histopathology confirmed subepidermal vesiculation rich in eosinophils.
• Direct immunofluorescence showed linear deposition of complement C3 and IgG along the basement membrane zone.

Implications:

• Pemphigoid gestationis requires consideration in the differential diagnosis of pruritic vesiculobullous eruptions during pregnancy.
• Accurate diagnosis and management are essential for maternal and fetal well-being.