Myelin basic protein (MBP) in human gliomas: a study of twenty-five cases

Twenty five gliomas (5 oligodendrogliomas, 8 oligoastrocytomas, 5 astrocytomas grades I-II, and 7 malignant astrocytomas-glioblastomas) were studied with the immunohistochemical technique avidin-biotin complex (ABC) for myelin basic protein (MBP). We found four patterns of positivity with variable degrees and frequencies in the different types of tumors. We believe this method can help in the diagnosis of non-characteristic gliomas, particularly oligoastrocytomas.