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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
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A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
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Systemic allergic dermatitis caused by Apiaceae root vegetables.

Evy Paulsen1, Thomas H Petersen, Xavier C Fretté

  • 1Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, DK-5000, Odense C, Denmark.

Contact Dermatitis
|October 10, 2013
PubMed
Summary
This summary is machine-generated.

Delayed-type hypersensitivity to Apiaceae root vegetables like carrots can occur. This case highlights non-occupational sensitization, suggesting falcarinol is not the primary allergen.

Keywords:
ApiacaeApium graveolens var. rapaceumDaucus carotaPastinaca sativaallergic contact dermatitiscarrotceleriacparsnippatch testingsystemic allergic dermatitis

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Area of Science:

  • Dermatology
  • Allergology
  • Plant Chemistry

Background:

  • Immediate hypersensitivity to Apiaceae (Umbelliferae) vegetables is common.
  • Delayed-type hypersensitivity reactions are infrequently documented.

Observation:

  • A patient presented with systemic contact dermatitis after consuming Apiaceae root vegetables.
  • Diagnostic testing included prick tests, patch tests, and chemical analysis.

Findings:

  • The patient exhibited contact sensitivity to celeriac, parsnip, and carrot.
  • Despite testing negative for falcarinol, the analyzed sample contained this compound.

Implications:

  • This case represents the first report of systemic contact dermatitis from Apiaceae root vegetables.
  • The findings suggest falcarinol may not be the causative agent in this type of non-occupational sensitization.