Systemic allergic dermatitis caused by Apiaceae root vegetables
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Updated: May 7, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
Evy Paulsen1, Thomas H Petersen, Xavier C Fretté
1Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, DK-5000, Odense C, Denmark.
Background:
Immediate hypersensitivity reactions to root vegetables of the Umbelliferae plant family (Apiaceae) is well known. Delayed-type hypersensitivity is rarely reported.
Objective:
To report the first case of systemic contact dermatitis caused by root vegetables and some chemical implications.
Materials And Methods:
Prick and patch testing were performed with fresh vegetables and selected allergens, and this was followed by high-performance liquid chromatography-mass spectrometry (MS)/MS analysis of the falcarinol syringe.
Results:
The patient was contact-sensitive to celeriac, parsnip, and carrot, but tested negative to falcarinol. Subsequent analysis showed that the syringe contained falcarinol.
Conclusion:
The non-occupational sensitization resulting from both direct and systemic contact with Apiaceae root vegetables was apparently not caused by falcarinol.
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