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Cynomolgus monkeys and morphine tolerance and dependence.

M D Aceto, L S Harris

Drug and Alcohol Dependence

|May 1, 1985

Summary

Cynomolgus monkeys showed tolerance and physical dependence to morphine, similar to rhesus monkeys. This indicates comparable responses to opioid administration across these primate species.

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Area of Science:

Pharmacology
Neuroscience
Primate Research

Background:

Opioid medications like morphine are widely used for pain management.
Understanding how different primate species respond to opioids is crucial for preclinical research.
Previous studies have established rhesus monkeys as a model for opioid effects.

Purpose of the Study:

To investigate the development of tolerance and physical dependence on morphine in cynomolgus monkeys.
To compare the effects of morphine in cynomolgus monkeys with those observed in rhesus monkeys.

Main Methods:

Administered a consistent dose regimen of morphine to cynomolgus monkeys.
Monitored for the development of tolerance (reduced response to the same dose) and physical dependence (withdrawal symptoms upon cessation).
Compared observed effects with historical data from rhesus monkeys receiving identical morphine regimens.

Main Results:

Cynomolgus monkeys readily developed tolerance to the effects of morphine.
Physical dependence on morphine was observed in cynomolgus monkeys.
The degree of tolerance and dependence in cynomolgus monkeys was indistinguishable from that seen in rhesus monkeys.

Conclusions:

Cynomolgus monkeys exhibit similar morphine-induced tolerance and physical dependence as rhesus monkeys.
Cynomolgus monkeys represent a valid model for studying opioid pharmacology and dependence.
Findings support the use of cynomolgus monkeys in preclinical opioid research.

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