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Related Experiment Video

Updated: May 7, 2026

A Protocol for Housing Mice in an Enriched Environment

A Protocol for Housing Mice in an Enriched Environment

Published on: June 8, 2015

Environmental enrichment and social interaction improve cognitive function and decrease reactive oxidative species in

Vanessa Doulames¹, Sangmook Lee, Thomas B Shea

¹Center for Cellular Neurobiology and Neurodegeneration Research, Department of Biological Sciences, University of Massachusetts Lowell , Lowell, MA , USA.

The International Journal of Neuroscience

|October 10, 2013

Summary

This summary is machine-generated.

Environmental and social enrichment boost cognitive performance in mice. Isolation in a standard environment worsened cognitive decline, while enrichment improved recognition memory regardless of housing conditions.

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Last Updated: May 7, 2026

A Protocol for Housing Mice in an Enriched Environment

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Published on: June 8, 2015

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Published on: December 29, 2014

Area of Science:

Neuroscience
Behavioral Science
Animal Models

Background:

Environmental stimulation and social interaction positively influence cognitive function.
Reduced stimulation or social isolation can accelerate cognitive decline due to various factors like aging or illness.

Purpose of the Study:

To investigate the effects of environmental stimulation and social interaction on cognitive performance in healthy adult mice.
To determine if environmental enrichment or social housing impacts cognitive function and brain oxidative stress markers.

Main Methods:

Adult C57B1/6J mice were housed individually or in groups of three for one month.
Housing conditions included a standard environment (SE) or an enriched environment (EE) with added exploratory items.
Cognitive performance was assessed using Y maze navigation and Novel Object Recognition (NOR) tests.

Main Results:

Mice isolated in the SE showed a significant decline in Y maze performance compared to baseline.
Group housing in the SE improved Novel Object Recognition (NOR) performance.
Environmental enrichment (EE) significantly enhanced NOR performance in both individually housed and group-housed mice.

Conclusions:

Environmental and social enrichment positively impact cognitive performance in healthy adult mice.
Proactive strategies involving environmental and social enrichment may help delay age-related cognitive decline.
Isolation in a standard environment may exacerbate cognitive decline, while enrichment offers protective benefits.