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Multiple sclerosis and cancer: when two wrongs make a right?
Ben Deery1, Vicki A Anderson, Mardee Greenham
1Psychology Department, Royal Children's Hospital , Melbourne , Australia.
Developmental Neurorehabilitation
|October 10, 2013
Summary
Immunoablation, a potent cancer therapy, led to a surprising six-year remission of multiple sclerosis (MS) symptoms in a teenage boy. This case highlights the potential of aggressive chemotherapy in treating refractory pediatric MS.
Area of Science:
- Neurology
- Pediatric Oncology
- Immunology
Background:
- Multiple sclerosis (MS) treatments are not universally effective, leaving some patients with refractory disease.
- Immunoablation, a high-risk therapy, shows promise in severe adult MS but its potential in pediatric cases is largely unexplored.
Observation:
- A 14-year-old male (MM) with a new diagnosis of MS also presented with Hodgkin's lymphoma.
- MM underwent aggressive chemotherapy, a form of immunoablation, for his lymphoma.
Findings:
- Following chemotherapy, MM experienced complete remission of his MS symptoms.
- He has remained free of MS progression and disease activity for over six years.
Implications:
- This case suggests a potential therapeutic role for immunoablation in refractory pediatric MS.
- Further investigation is warranted to understand the long-term effects and cognitive/behavioral development in such cases.
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