Related Experiment Video

Updated: May 7, 2026

Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine
12:37

Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine

Published on: February 9, 2016

12.5K

Umbilical cord vitamin D, ionized calcium and myocardial oxygen demand

Inez Reeves1, Willie Liang, M Sadegh Asadi

  • 1Division of Neonatology, Department of Obstetrics and Gynecology .

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|October 10, 2013
PubMed

Insights

Low vitamin D and calcium in umbilical cord blood of newborns with low birthweight (LBW) correlate with lower heart rate-systolic pressure product (RPP), indicating potential issues in heart development.

Area of Science:

  • Neonatal physiology
  • Cardiovascular health
  • Nutritional science

Background:

  • Systemic vitamin D and calcium levels are linked to birthweight and cardiovascular disease.
  • The relationship between umbilical cord blood levels of vitamin D and ionized calcium with birthweight and cardiovascular function remains unclear.

Purpose of the Study:

  • To investigate the correlation between umbilical cord blood vitamin D and ionized calcium levels, birthweight, and the heart rate-systolic pressure product (RPP) in newborns.
  • To assess RPP as an indicator of myocardial oxygen demand in relation to cord blood nutrient status and birthweight.

Main Methods:

  • A cross-sectional study comparing cord blood vitamin D and ionized calcium in normal weight and low birthweight (LBW) newborns.
  • Measurement of heart rate and blood pressure during postnatal transition to compute RPP.

Main Results:

  • RPP showed a positive correlation with birthweight and cord ionized calcium in both normal and LBW newborns.
  • In LBW newborns, RPP was positively correlated with cord vitamin D levels.

Conclusions:

  • Low RPP in LBW newborns is associated with low umbilical cord vitamin D and ionized calcium levels.
  • These findings suggest a potential link between low cord nutrient status and pathological heart development in LBW infants.
Abstract

Keywords:
Birthweightrate-pressure productumbilical cord bloodvitamin D deficiency

More Related Videos

Intra-cardiac Side-Firing Light Catheter for Monitoring Cellular Metabolism using Transmural Absorbance Spectroscopy of Perfused Mammalian Hearts08:51

Intra-cardiac Side-Firing Light Catheter for Monitoring Cellular Metabolism using Transmural Absorbance Spectroscopy of Perfused Mammalian Hearts

Published on: May 12, 2019

8.8K
Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells06:47

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

8.8K

Related Concept Videos

Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
8.5K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.1K
Introduction to Electrolytes01:33

Introduction to Electrolytes

In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
Role of Sodium
One...
12.6K
Fetal Circulation01:14

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
5.1K
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
8.2K
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
2.2K