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Cluster analysis identifies characteristic phenotypes of asthma with accelerated lung function decline
Takuro Sakagami1, Takashi Hasegawa, Toshiyuki Koya
1Division of Respiratory Medicine, Department of Homeostatic Regulation and Development, Graduate School of Medical and Dental Sciences, Niigata University , Niigata , Japan and.
Summary
A subgroup of asthma patients experience accelerated lung function decline, even with guideline-based treatment. Identifying these patients is crucial for personalized asthma management and preserving lung health.
Area of Science:
- Pulmonology
- Clinical Medicine
- Asthma Research
Background:
- Asthma management aims to preserve lung function, but some patients experience accelerated decline.
- The effectiveness of current asthma guidelines in preventing lung function decline is debated.
Purpose of the Study:
- To determine the prevalence of accelerated lung function decline in asthma patients.
- To identify clinical characteristics of asthma patients with significant lung function decline despite guideline-adherent treatment.
Main Methods:
- Utilized hierarchical cluster analysis on data from 86 non-smoking asthma patients.
- Assessed eight clinical phenotype variables using step-wise multiple regression analysis.
Main Results:
- Identified three distinct patient clusters.
- Cluster 3, comprising older men with late-onset asthma, showed the greatest mean decline in forced expiratory volume in 1 second (FEV1) at 69 mL/year.
- This subgroup had lower baseline predicted %FEV1 and fewer exacerbations.
Conclusions:
- A specific subgroup of asthma patients experiences accelerated lung function decline.
- This decline occurs despite treatment aligned with current asthma guidelines.
- Further research is needed to tailor asthma management for these individuals.
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