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Diabetes mellitus and abnormalities in semen analysis
Sudhindra Mohan Bhattacharya1, Mainak Ghosh, Nupur Nandi
1S.C.Das Memorial Medical and Research Center, Jodhpur Park, Kolkata, India; Department of Obstetrics and Gynecology, KPC Medical College, Jadavpur, Kolkata, India.
The Journal of Obstetrics and Gynaecology Research
|October 10, 2013
Summary
Diabetes mellitus significantly impairs male fertility by negatively affecting sperm parameters such as motility, morphology, and DNA integrity. This study highlights diabetes as a key factor in male-factor infertility.
Area of Science:
- Reproductive Medicine
- Endocrinology
- Andrology
Background:
- Male infertility is a significant concern in reproductive medicine.
- Diabetes mellitus is a systemic disease with potential widespread effects on male reproductive health.
Purpose of the Study:
- To compare semen parameters between diabetic and non-diabetic men.
- To investigate the impact of diabetes mellitus on sperm quality and DNA integrity.
Main Methods:
- A case-control study comparing 52 diabetic men with 66 non-diabetic men.
- Semen analysis included WHO criteria, hypo-osmotic swelling test, and Acridine Orange test for DNA integrity.
- Body mass index and glycosylated hemoglobin levels were also assessed.
Main Results:
- Diabetic men showed significantly reduced ejaculate volume, total sperm count, and motility (P < 0.001).
- Sperm morphology, hypo-osmotic swelling test results, and DNA integrity were also significantly lower in the diabetic group (P < 0.05).
- No significant differences in age or BMI were observed between groups.
Conclusions:
- Diabetes mellitus adversely affects spermatogenesis at multiple levels.
- These impairments in sperm parameters contribute to male-factor infertility in diabetic individuals.
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