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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Progression of aortic pulse wave velocity in patients with chronic kidney disease

Susanne Tholen1, Katharina Klofat, Cheng Rui Pan

  • 1Department of Nephrology, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.

Journal of Clinical Hypertension (Greenwich, Conn.)
|October 10, 2013
PubMed

Insights

Arterial stiffness, measured by aortic pulse wave velocity (aPWV), significantly worsens in chronic kidney disease (CKD) patients over one year. Age, blood pressure, and diabetes accelerate this progression, highlighting cardiovascular risk factors in CKD.

Area of Science:

  • Cardiovascular Physiology
  • Nephrology
  • Medical Science

Background:

  • Aortic pulse wave velocity (aPWV) is elevated in chronic kidney disease (CKD) patients, indicating increased cardiovascular risk.
  • The natural progression of arterial stiffness and its determinants in CKD patients are not fully understood.

Purpose of the Study:

  • To investigate the progression of aPWV in CKD patients over 12 months.
  • To identify factors associated with the acceleration of aPWV progression in this cohort.

Main Methods:

  • aPWV was measured in 70 CKD patients at baseline and after 12 months.
  • Correlations were analyzed between aPWV changes and variables including glomerular filtration rate reduction and diabetes mellitus.
  • Patients were divided into stable and progressive aPWV groups to identify associated factors.

Main Results:

  • aPWV significantly increased by 1.1 m/s in the cohort over 1 year (P<.01).
  • Accelerated aPWV progression was associated with older age, higher systolic blood pressure, and diabetes mellitus.
  • The rate of renal function decline (glomerular filtration rate reduction) did not significantly impact aPWV progression.

Conclusions:

  • Annual aPWV progression in CKD patients averages 1 m/s, signifying heightened cardiovascular risk.
  • Age, systolic blood pressure, and diabetes are key factors driving arterial stiffness progression in CKD.
  • Further research is needed to evaluate variables contributing to progressive arterial stiffness in CKD.

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