Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structure-function relationships in H+-secreting epithelia.

K M Madsen, C C Tisher

    Federation Proceedings
    |August 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cord occlusion, division and disentanglement in complicated monochorionic monoamniotic twin pregnancy.

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2022
    Same author

    Adeno-associated viral vector-mediated interleukin-10 prolongs allograft survival in a rat kidney transplantation model.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2007
    Same author

    Influence of ET(B) receptor antagonism on pregnancy outcome in rats.

    Journal of the Society for Gynecologic Investigation·2001
    Same author

    Strategies for influencing outcomes in pre-ESRD and ESRD patients.

    Journal of the American Society of Nephrology : JASN·2001
    Same author

    Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial.

    JAMA·2001
    Same author

    Risk and patterns of bacteraemia after splenectomy: a population-based study.

    Scandinavian journal of infectious diseases·2000
    Same journal

    ASBESTOS FIBERS MEDIATE THE UPTAKE OF DNA INTO PRIMATE CELLS IN CULTURE.

    Federation proceedings·2018
    Same journal

    Chemical protection of mammalian tissues.

    Federation proceedings·2014
    Same journal

    Dietary requirements for fertility and lactation; dried yeasts as sources of proteins and vitamin B complex for growth, reproduction and lactation.

    Federation proceedings·2010
    Same journal

    On the mode of action of chlorinating compounds.

    Federation proceedings·2010
    Same journal

    d-Amino acid oxidase of Proteus morganii.

    Federation proceedings·2010
    Same journal

    Studies on thymus nucleohistone.

    Federation proceedings·2010
    See all related articles

    Stimulating H+ secretion in epithelial cells involves ultrastructural changes, suggesting membrane transfer from internal compartments to the cell surface. This membrane recycling mechanism is key to regulating acid secretion.

    Area of Science:

    • Cell biology
    • Epithelial physiology
    • Membrane trafficking

    Background:

    • H+ secretion is vital in gastric, urinary bladder, and kidney collecting duct epithelial cells.
    • Different H+ pumps (H+-ATPase) exist across these cell types.
    • Common ultrastructural features are observed in these acid-secreting cells.

    Purpose of the Study:

    • To investigate the ultrastructural changes associated with H+ secretion stimulation.
    • To explore the relationship between membrane structures and H+ pump activity.
    • To propose a mechanism for morphological adaptation during acid secretion.

    Main Methods:

    • Comparative analysis of parietal cells, turtle bladder cells, and mammalian collecting duct cells.
    • Morphometric analysis of ultrastructural changes.

    Related Experiment Videos

  • Observation of mitochondrial abundance, tubulovesicular structures, and apical membrane surface area.

    • Main Results:

    • Stimulation of H+ secretion led to increased apical membrane surface area.
    • A concurrent decrease in apical tubulovesicular membrane structures was observed.
    • These changes suggest a dynamic membrane redistribution process.

    Conclusions:

    • A membrane recycling hypothesis is proposed to explain the observed morphological changes.
    • Membrane, potentially containing H+ pumps, is transferred to the apical surface upon stimulation.
    • This mechanism facilitates efficient regulation of H+ secretion.