Does estimated glomerular filtration rate have an effect on left ventricular function after ST-elevation myocardial...

Area of Science:

• Cardiology
• Nephrology
• Medical Imaging

Background:

• Estimated glomerular filtration rate (eGFR) is a key indicator of kidney function.
• Left ventricular (LV) function is crucial post-ST-elevation myocardial infarction (STEMI).
• The impact of eGFR on LV function and treatment response in STEMI patients is not well understood.

Purpose of the Study:

• To investigate the effect of eGFR on LV function using tissue Doppler imaging (TDI) in STEMI patients.
• To evaluate the antiremodeling effect of standard treatment in STEMI patients with renal insufficiency (RI).

Main Methods:

• Retrospective analysis of 579 STEMI patients.
• Patients categorized into three groups based on eGFR (<60, 60-89, >90 mL/min per 1.73 m²).
• Echocardiography and TDI performed at baseline and 6-month follow-up.

Main Results:

• Lower mean left ventricular ejection fraction (LVEF) and peak systolic velocity (Sm) observed in patients with eGFR < 60.
• eGFR showed a linear association with Sm and LVEF.
• eGFR < 60 mL/min per 1.73 m² independently predicted lower Sm and increased in-hospital mortality.
• Standard treatment demonstrated antiremodeling effects across all eGFR groups at follow-up.

Conclusions:

• An eGFR < 60 mL/min per 1.73 m² is associated with impaired LV function post-STEMI.
• STEMI patients with reduced eGFR may benefit from standard antiremodeling treatments.
• Further research into renal function's role in cardiac recovery post-STEMI is warranted.