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Does estimated glomerular filtration rate have an effect on left ventricular function after ST-elevation myocardial

Osman Sonmez1, Mehmet A Vatankulu, Abdurrahman Tasal

  • 1Cardiology Department, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.

Echocardiography (Mount Kisco, N.Y.)
|October 10, 2013
PubMed

Insights

Reduced kidney function (eGFR < 60) is linked to poorer left ventricular (LV) function after ST-elevation myocardial infarction (STEMI). Standard treatment shows antiremodeling benefits for these patients.

Area of Science:

  • Cardiology
  • Nephrology
  • Medical Imaging

Background:

  • Estimated glomerular filtration rate (eGFR) is a key indicator of kidney function.
  • Left ventricular (LV) function is crucial post-ST-elevation myocardial infarction (STEMI).
  • The impact of eGFR on LV function and treatment response in STEMI patients is not well understood.

Purpose of the Study:

  • To investigate the effect of eGFR on LV function using tissue Doppler imaging (TDI) in STEMI patients.
  • To evaluate the antiremodeling effect of standard treatment in STEMI patients with renal insufficiency (RI).

Main Methods:

  • Retrospective analysis of 579 STEMI patients.
  • Patients categorized into three groups based on eGFR (<60, 60-89, >90 mL/min per 1.73 m²).
  • Echocardiography and TDI performed at baseline and 6-month follow-up.

Main Results:

  • Lower mean left ventricular ejection fraction (LVEF) and peak systolic velocity (Sm) observed in patients with eGFR < 60.
  • eGFR showed a linear association with Sm and LVEF.
  • eGFR < 60 mL/min per 1.73 m² independently predicted lower Sm and increased in-hospital mortality.
  • Standard treatment demonstrated antiremodeling effects across all eGFR groups at follow-up.

Conclusions:

  • An eGFR < 60 mL/min per 1.73 m² is associated with impaired LV function post-STEMI.
  • STEMI patients with reduced eGFR may benefit from standard antiremodeling treatments.
  • Further research into renal function's role in cardiac recovery post-STEMI is warranted.
Abstract

Keywords:
acute myocardial infarctionglomerular filtration rateleft ventricle remodelingrenal insufficiencytissue Doppler

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