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Incidence of intussusception in Singaporean children aged less than 2 years: a hospital-based prospective study

Kong Boo Phua1, Bee-Wah Lee, Seng Hock Quak

  • 1KK Women's and Children's Hospital, Singapore, Singapore. Phua.Kong.Boo@kkh.com.sg.

BMC Pediatrics
|October 10, 2013
PubMed

Insights

Surveillance for intussusception (IS) in Singapore found a low and stable incidence in children under two years old. This monitoring is crucial for assessing the safety of rotavirus vaccines.

Area of Science:

  • Pediatric Gastroenterology
  • Vaccine Safety Surveillance
  • Epidemiology

Background:

  • Continuous surveillance for intussusception (IS) is vital for monitoring the safety of second-generation rotavirus vaccines.
  • The study assessed the incidence of IS in Singaporean children under two years of age.

Purpose of the Study:

  • To determine the incidence of intussusception (IS) in children younger than two years in Singapore.
  • To provide data for ongoing rotavirus vaccine safety monitoring.

Main Methods:

  • A prospective, hospital-based, multi-center surveillance study was conducted in Singapore from May 2002 to June 2010.
  • Diagnosis of IS followed the Brighton Collaboration case definition.
  • Incidence was calculated per 100,000 child-years for children under two years.

Main Results:

  • 167 definite IS cases were analyzed in children under two years old.
  • The overall incidence of IS was 26.1 per 100,000 child-years.
  • Most children recovered, with a few experiencing sequelae or mortality.

Conclusions:

  • The incidence of intussusception (IS) in Singaporean children under two years remained low and stable during the study period.
  • Findings support the continued safe use of rotavirus vaccines.
  • This surveillance data is essential for public health.
Abstract

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