Related Experiment Video
Updated: May 7, 2026
07:28
Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery
Published on: February 3, 2026
266
[Pregnancy after isotretinoin use]
Klaartje C Manders1, Loes C de Vries, Frans J M E Roumen
1Elkerliek Ziekenhuis, afd. Gynaecologie en Obstetrie, Helmond.
Nederlands Tijdschrift Voor Geneeskunde
|October 10, 2013
Summary
Isotretinoin effectively treats acne but is teratogenic. A healthy baby was born to a mother who conceived shortly after isotretinoin, suggesting individualized risk assessment is crucial for pregnancy.
Area of Science:
- Dermatology
- Teratology
- Obstetrics
Background:
- Isotretinoin is a common acne treatment with high teratogenic potential.
- Pregnancy prevention programs mandate contraception during and after isotretinoin therapy.
Observation:
- A 29-year-old woman conceived shortly after discontinuing isotretinoin.
- She opted to continue the pregnancy despite teratogenicity concerns.
- An uneventful pregnancy resulted in a healthy infant.
Findings:
- Individualized risk assessment for congenital abnormalities is possible.
- Accurate dating of conception and isotretinoin cessation is key.
Implications:
- Contraception is essential for women of reproductive age using isotretinoin.
- Personalized risk evaluation can guide management in accidental pregnancies.
- This case highlights the importance of informed decision-making in teratogen exposure during pregnancy.
Related Concept Videos
01:27Acne Infection
99
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
99
01:07Teratogenicity
4.2K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.2K
01:22Birth Control Methods
5.6K
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
5.6K
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
703
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
703
01:21Intrauterine Drug Delivery Systems
170
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
170
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
780
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
780