[Temporal regulation of abscission, the last step of cell division]

Cell division is one of the most tightly controlled steps of the cell cycle. Indeed, the many steps of cell division have to be perfectly coordinated both in time and space in order to ensure an error-free division and an accurate transmission of the genome from the mother cell to the two daughter cells. Abscission, the last step of cytokinesis, consists in the severing of the intercellular bridge that connects the two daughter cells after the contraction of the acto-myosin ring. As is the case for any other step of cell division, abscission has to be precisely regulated in order to take place at the right time and the proper place. Whereas the spatial regulation of abscission is quite well understood, the study of temporal regulation is in its infancy. This review begins by describing the formation of the intercellular bridge, its organization, and its composition. Next the different models of abscission are discussed. Finally, the current understanding of the temporal regulation of abscission is detailed. In particular, I present my recent results on the role of forces exerted by the daughter cells on the intercellular bridge.