Multi-nutrient supplement improves hormone ratio associated with cancer risk

Area of Science:

• Endocrinology
• Gynecology
• Nutritional Science

Background:

• Gynecological cancers are linked to hormonal factors, particularly the ratio of 2-hydroxyestrone (2-HE) to 16alpha-hydroxyestrone (16alpha-HE).
• Botanical compounds like indoles, flavonoids, and resveratrol may favorably influence estrogen metabolism pathways.
• The 2-HE/16alpha-HE ratio is a potential biomarker for gynecological malignancy risk.

Purpose of the Study:

• To evaluate the effect of a multi-nutrient supplement containing botanical constituents on the 2-HE/16alpha-HE ratio.
• To assess if targeted phytonutrients can modulate estrogen metabolite ratios in middle-aged women.

Main Methods:

• Retrospective analysis of 76 middle-aged women with ratio assessments at two time points.
• Comparison between 65 women taking a multi-nutrient supplement (Lucentia Peak) and 11 controls.
• Paired t-tests used to analyze changes in 2-HE, 16alpha-HE, and their ratio within and between groups.

Main Results:

• The treated group showed a significant increase in the 2-HE/16alpha-HE ratio (0.38 to 0.57, p<0.0001).
• This increase was significantly different compared to the control group (p=0.02).
• The ratio change was primarily mediated by an increase in 2-HE levels.

Conclusions:

• Lucentia Peak supplementation led to significant increases in the 2-HE:16alpha-HE ratio, mainly by elevating 2-HE.
• These findings suggest phytonutrients may positively impact estrogen metabolism.
• Further research into phytonutrients for estrogen metabolism is recommended.