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Decoupling of QT interval variability from heart rate variability with ageing
Mathias Baumert1, Barbora Czippelova, Alberto Porta
1School of Electrical and Electronic Engineering and Centre for Heart Rhythm Disorders, The University of Adelaide, Adelaide, Australia.
Physiological Measurement
|October 10, 2013
Summary
Ageing decouples QT interval variability from heart rate variability, indicated by prolonged QT intervals and altered complexity measures in elderly individuals. This suggests changes in cardiac electrophysiology with aging.
Area of Science:
- Cardiology
- Gerontology
- Biophysics
Background:
- Aging is linked to cardiac electrophysiology changes, including QT interval prolongation.
- The impact of aging on the dynamic adaptation of the QT interval to heart rate is not fully understood.
Purpose of the Study:
- To investigate age-related alterations in the temporal coupling between QT and RR interval variability.
- To assess how aging affects the dynamic relationship between cardiac electrical activity and heart rate.
Main Methods:
- Analysis of resting ECG data from 20 young and 20 elderly healthy subjects.
- Extraction of beat-to-beat RR and QT interval time series.
- Assessment of QT-RR coupling using QT variability index, frequency domain coherence, rate-corrected QT interval, cross-multiscale entropy, information-based similarity index, and joint symbolic dynamics.
Main Results:
- Elderly subjects exhibited significantly prolonged QT intervals (433 ± 31 ms vs. 405 ± 33 ms).
- Increased QT variability index, reduced coherence in low and high frequency bands, and decreased information domain synchronization were observed in the elderly.
- Higher entropy and disparity in joint symbolic dynamics of QT and RR intervals were noted in older individuals.
Conclusions:
- Aging is associated with a decoupling of QT variability from heart rate variability.
- Complexity analysis offers valuable insights into age-related cardiac electrophysiological changes beyond standard metrics.
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