Related Experiment Video

Updated: May 7, 2026

Conjunctival Commensal Isolation and Identification in Mice
07:52

Conjunctival Commensal Isolation and Identification in Mice

Published on: May 1, 2021

3.6K

Multidrug-resistant bacteria induce recurrent keratoconjunctivitis in a patient with common variable

Jiang Chao1, Zhou Yumei, Wang Zhiqun

  • 1Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China.

Cornea
|October 10, 2013
PubMed
Abstract

Insights

Recurrent keratoconjunctivitis can be an early sign of common variable immunodeficiency (CVID). Prompt diagnosis and treatment with intravenous immunoglobulin (IVIG) are crucial for managing this condition.

Area of Science:

  • Ophthalmology
  • Immunology
  • Infectious Diseases

Background:

  • Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by impaired antibody production.
  • Ocular manifestations, such as recurrent infections, can be presenting symptoms of CVID.

Observation:

  • A 33-year-old male presented with recurrent, multidrug-resistant bacterial keratoconjunctivitis.
  • Initial topical vancomycin treatment provided temporary relief but was insufficient to prevent recurrence upon cessation.

Findings:

  • The patient was diagnosed with CVID after systemic immune evaluation.
  • Treatment with intravenous immunoglobulin (IVIG) resulted in complete resolution of ocular infections.
  • Long-term monthly IVIG administration is planned for lifelong management.

Implications:

  • Keratoconjunctivitis may be the initial clinical presentation of CVID.
  • Unexplained recurrent bacterial conjunctival and corneal infections warrant investigation for underlying immunodeficiency.
  • Systemic management with IVIG is essential for CVID-associated ocular infections, as topical therapies are inadequate.

More Related Videos

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

15.8K
Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK07:27

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Published on: December 18, 2012

11.3K

Related Concept Videos

Microbiome of the Eye01:22

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
75
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
3.8K
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
108
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
115
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable...
100
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
49