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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Related Experiment Video

Updated: May 7, 2026

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound
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High-risk features in radiation-associated breast angiosarcomas.

S P D'Angelo1, C R Antonescu, D Kuk

  • 11] Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA [2] Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.

British Journal of Cancer
|October 10, 2013
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Radiation-associated breast angiosarcoma (RT-AS) is rare but aggressive, with high recurrence rates and poor survival. Older age and deep tumors are linked to worse outcomes in patients with RT-AS.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiation Oncology

Background:

  • Radiation-associated breast angiosarcoma (RT-AS) is a rare malignancy, accounting for less than 1% of soft tissue sarcomas.
  • Patients with RT-AS face a dismal prognosis, characterized by high recurrence rates and poor overall survival.
  • Limited data exists on the clinical outcomes for patients diagnosed with breast RT-AS.

Purpose of the Study:

  • To investigate the clinical outcomes of patients diagnosed with radiation-associated breast angiosarcoma.
  • To identify prognostic factors influencing disease-specific survival in RT-AS patients.

Main Methods:

  • A retrospective review of patients with RT-AS treated at Memorial Sloan-Kettering Cancer Center from 1982 to 2011.
  • Collection and analysis of correlative clinical information for identified patients.

Main Results:

  • Seventy-nine women with RT-AS were identified, with a median age of 68 years.
  • The median interval between radiation exposure and RT-AS diagnosis was 7 years.
  • High rates of local (1.29 years) and distant (2.48 years) recurrence were observed, with a median disease-specific survival of 2.97 years.
  • Independent predictors of worse disease-specific survival included age ≥68 years and deep tumor location.

Conclusions:

  • RT-AS exhibits high local and distant recurrence rates.
  • Standard chemotherapy offers limited duration of benefit for RT-AS.
  • The disease is associated with poor disease-specific survival, with age and tumor depth as significant prognostic factors.