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Common-path spectral interferometry with temporal carrier for highly sensitive surface plasmon resonance sensing.

Siu Pang Ng, Fong Chuen Loo, Shu Yuen Wu

    Optics Express
    |October 10, 2013
    PubMed
    Summary

    We developed a novel surface plasmon resonance (SPR) biosensing system achieving high refractive index resolution (RIR) of 2 × 10(-8) RIU. This advanced system offers a wide dynamic range and a simpler optical setup for practical biosensing applications.

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    Area of Science:

    • Optics and Photonics
    • Biomedical Engineering
    • Nanotechnology

    Background:

    • Surface Plasmon Resonance (SPR) is a label-free optical technique widely used for biosensing.
    • Existing SPR systems face challenges in achieving high resolution and dynamic range simultaneously.
    • Spectral interferometry and temporal carrier techniques offer potential for enhanced SPR performance.

    Purpose of the Study:

    • To demonstrate an advanced SPR biosensing system with improved refractive index resolution (RIR) and dynamic range.
    • To address spectral phase discontinuity issues in SPR measurements.
    • To develop a simpler and more practical optical setup for SPR sensing.

    Main Methods:

    • Integration of the temporal carrier technique with common-path spectral interferometry.
    • Optimization of SPR differential phase sensing conditions using a gold layer.
    • Implementation of a novel spectral-temporal phase measurement scheme to resolve spectral phase discontinuity.

    Main Results:

    • Achieved a refractive index resolution (RIR) of 2 × 10(-8) refractive index unit (RIU).
    • Demonstrated a wide dynamic range of 3 × 10(-2) RIU.
    • Developed a simplified optical setup compared to traditional Michelson interferometers.

    Conclusions:

    • The developed SPR biosensing system offers significant improvements in resolution and dynamic range.
    • The novel spectral-temporal phase measurement scheme effectively addresses spectral phase discontinuity.
    • The simplified optical design makes the system suitable for practical SPR sensing applications.